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Article

Genetic determinants of activated factor VII-antithrombin plasma levels and mortality in patients with coronary artery disease.

Thrombosis research - 1 Oct 2025

Osti Nicola, Musuraca Gerardo, Lunghi Barbara, Donini Martino, Presa Francesco, Jarriullah Hafiz, Spizzo Marianna, Mango Gabriele, Pattini Patrizia, Argentino Giuseppe, Castagna Annalisa, Baroni Marcello, Grusse Matthieu, Pizzolo Francesca, Ferro Antonio, Van Dreden Patrick, Girelli Domenico, Friso Simonetta, Bernardi Francesco, Martinelli Nicola

Abstract excerpt

BACKGROUND: Activated factor VII-antithrombin complex (FVIIa-AT) is an indirect plasma biomarker of the interaction between tissue factor (TF) and FVIIa. High FVIIa-AT levels have been associated with an increased risk of mortality. METHODS: We investigated the genetic determinants of FVIIa-AT plasma levels by a candidate gene approach in a cohort of 610 subjects with (n = 478) or without (n = 132)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40939340
DOI: 10.1016/j.thromres.2025.109459

Genes

CAD
TF
F3
F7
LRP1

Variants

Provenance

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