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Article

Coagulation factor XII genetic variation, ex vivo thrombin generation, and stroke risk in the elderly: results from the Cardiovascular Health Study.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2015

Olson N C, Butenas S, Lange L A, Lange E M, Cushman M, Jenny N S, Walston J, Souto J C, Soria J M, Chauhan G, Debette S, Longstreth W T, Seshadri S, Reiner A P, Tracy R P

Abstract excerpt

BACKGROUND: The relationships of thrombin generation (TG) with cardiovascular disease risk are underevaluated in population-based cohorts. OBJECTIVES: To evaluate the relationships of TG influenced by the contact and tissue factor coagulation pathways ex vivo with common single-nucleotide polymorphisms (SNPs) and incident cardiovascular disease and stroke. PATIENTS/METHODS: We measured peak TG (pTG) in baseline...

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Identifiers

PMID: 26286125
DOI: 10.1111/jth.13111
PMCID: PMC4946166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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