Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EMPhasis on Mutant Microglia: Dysregulation of Brain Sentinels Induces Neurodegeneration.

Cell stem cell - 2 Nov 2017

Schreiner Bettina, Greter Melanie

Abstract excerpt

Reactive microglia are often implicated in the pathology of neurodegenerative disease. In a recent study in Nature, Mass et al. (2017) demonstrate that targeted mutation of Braf in early erythro-myeloid precursors (EMPs) causes histiocytosis-associated late onset neurodegeneration driven by activated microglia.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Microglia
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloid Progenitor Cells

Share to Neurodegenerative Diseases

Source

Identifiers

PMID: 29100009
DOI: 10.1016/j.stem.2017.10.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EMPhasis on Mutant Microglia: Dysregulation of Brain Sentinels Induces Neurodegeneration.PMID 29100009Read ↗

A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease.Semantic proximity Read ↗

Mechanism of neurodegeneration mediated by clonal inflammatory microgliaSemantic proximity Read ↗

Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegenerationSemantic proximity Read ↗

Pathogenic myeloid phenotypes drive disease pathology in a novel human neurohistiocytosis model.Semantic proximity Read ↗

Microglia as neuroprotective, immunocompetent cells of the CNSSemantic proximity Read ↗

Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy.Semantic proximity Read ↗

Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2Semantic proximity Read ↗

A microglia clonal inflammatory disorder in Alzheimer's disease.Semantic proximity Read ↗

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseasesSemantic proximity Read ↗

Gpnmb Defines a Phagocytic State of Microglia Linked to Neuronal Loss in Prion DiseaseSemantic proximity Read ↗

Oncogenic BRAF V600E induces glial proliferation through ERK and neuronal death through JNKSemantic proximity Read ↗

Genetically engineered microglia-like cells have therapeutic potential for neurodegenerative diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.