Article

Oncogenic BRAF V600E induces glial proliferation through ERK and neuronal death through JNK

2021-03-20

Abstract excerpt

<title>Abstract</title> <p>Background: Activating V600E in BRAF is a common driver mutation in cancers of multiple tissue origins, including melanoma and glioma. BRAF V600E has also been implicated in neurodegeneration. The present study aims to characterize BRAF V600E on cell death and survival in three major cell types of the CNS: neurons, astrocytes, and microglia. Methods : Multiple primary cultures and cell...

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Literature Corpus work: 95eef6b9-116c-5803-8dfc-b7f80c09f75e
DOI: 10.21203/rs.3.rs-220057/v2

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