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Article

A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease.

Nature - 21 Sept 2017

Mass Elvira, Jacome-Galarza Christian E, Blank Thomas, Lazarov Tomi, Durham Benjamin H, Ozkaya Neval, Pastore Alessandro, Schwabenland Marius, Chung Young Rock, Rosenblum Marc K, Prinz Marco, Abdel-Wahab Omar, Geissmann Frederic

Abstract excerpt

The pathophysiology of neurodegenerative diseases is poorly understood and there are few therapeutic options. Neurodegenerative diseases are characterized by progressive neuronal dysfunction and loss, and chronic glial activation. Whether microglial activation, which is generally viewed as a secondary process, is harmful or protective in neurodegeneration remains unclear. Late-onset neurodegenerative disease...

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Identifiers

PMID: 28854169
DOI: 10.1038/nature23672
PMCID: PMC6047345

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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