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DNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions

19 Aug 2010

Abstract excerpt

BACKGROUND: Mitochondria are semi-autonomous, semi-self-replicating organelles harboring their own DNA (mitochondrial DNA, mtDNA), and their dysregulation is involved in the development of various diseases. While mtDNA does not generally undergo epigenetic modifications, almost all mitochondrial proteins are encoded by nuclear DNA. However, the epigenetic regulation of nuclear-encoded mitochondrial genes (nuclear...

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PMID: 20723256
DOI: 10.1186/1471-2164-11-481

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