Novel HLA class I associations with HIV-1 control in a unique genetically admixed population.

doi:10.1038/s41598-018-23849-7

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Article

Novel HLA class I associations with HIV-1 control in a unique genetically admixed population.

Scientific reports - 17 Apr 2018

Valenzuela-Ponce Humberto, Alva-Hernández Selma, Garrido-Rodríguez Daniela, Soto-Nava Maribel, García-Téllez Thalía, Escamilla-Gómez Tania, García-Morales Claudia, Quiroz-Morales Verónica Sonia, Tapia-Trejo Daniela, Del Arenal-Sánchez Silvia, Prado-Galbarro Francisco-Javier, Hernández-Juan Ramón, Rodríguez-Aguirre Edna, Murakami-Ogasawara Akio, Mejía-Villatoro Carlos, Escobar-Urias Ingrid Y, Pinzón-Meza Rodolfo, Pascale Juan Miguel, Zaldivar Yamitzel, Porras-Cortés Guillermo, Quant-Durán Carlos, Lorenzana Ivette, Meza Rita I, Palou Elsa Y, Manzanero Marvin, Cedillos Rolando A, Aláez Carmen, Brockman Mark A, Harrigan P Richard, Brumme Chanson J, Brumme Zabrina L, Ávila-Ríos Santiago, Reyes-Terán Gustavo

Abstract excerpt

Associations between HLA class I alleles and HIV progression in populations exhibiting Amerindian and Caucasian genetic admixture remain understudied. Using univariable and multivariable analyses we evaluated HLA associations with five HIV clinical parameters in 3,213 HIV clade B-infected, ART-naïve individuals from Mexico and Central America (MEX/CAM cohort). A Canadian cohort (HOMER, n = 1622) was used for...

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Identifiers

PMID: 29666450
DOI: 10.1038/s41598-018-23849-7
PMCID: PMC5904102

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