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Article

Mutational signatures of non-homologous and polymerase theta-mediated end-joining in embryonic stem cells.

The EMBO journal - 15 Dec 2017

Schimmel Joost, Kool Hanneke, van Schendel Robin, Tijsterman Marcel

Abstract excerpt

Cells employ potentially mutagenic DNA repair mechanisms to avoid the detrimental effects of chromosome breaks on cell survival. While classical non-homologous end-joining (cNHEJ) is largely error-free, alternative end-joining pathways have been described that are intrinsically mutagenic. Which end-joining mechanisms operate in germ and embryonic cells and thus contribute to heritable mutations found in...

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Identifiers

PMID: 29079701
DOI: 10.15252/embj.201796948
PMCID: PMC5730883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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