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Article

Mispaired rNMPs in DNA are mutagenic and are targets of mismatch repair and RNases H.

Nature structural & molecular biology - 4 Dec 2011

Shen Ying, Koh Kyung Duk, Weiss Bernard, Storici Francesca

Abstract excerpt

Numerous studies have shown that ribonucleoside monophosphates (rNMPs) are probably abundant among all nonstandard nucleotides occurring in genomic DNA. Therefore, it is important to understand to what extent rNMPs may alter genome integrity and what factors affect their stability. We developed oligonucleotide-driven gene correction assays in Escherichia coli and Saccharomyces cerevisiae to show that mispaired...

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Identifiers

PMID: 22139012
DOI: 10.1038/nsmb.2176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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