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Article

Impact of a CD4 gene haplotype on the immune response in minipigs.

Immunogenetics - 1 Apr 2018

Blanc Fany, Créchet Françoise, Bruneau Nicolas, Piton Guillaume, Leplat Jean-Jacques, Andréoletti Fabrice, Egidy Giorgia, Vincent-Naulleau Silvia, Bourneuf Emmanuelle

Abstract excerpt

The cluster of differentiation 4 (CD4) molecule functions as a co-receptor for MHC class II binding to TCR in T helper cells. A CD4 epitope deficiency was identified in the swine MeLiM (melanoblastoma-bearing Libechov minipig) strain, a model for spontaneous cutaneous melanoma development and regression. Extensive sequencing revealed a high genetic variability of CD4 and the existence of several haplotypes...

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Share to CD4 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Homology, Nucleic Acid

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Source

Identifiers

PMID: 29052750
DOI: 10.1007/s00251-017-1037-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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