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Article

Detection of novel quantitative trait loci for cutaneous melanoma by genome-wide scan in the MeLiM swine model.

International journal of cancer - 15 Jan 2007

Du Zhi-Qiang, Vincent-Naulleau Silvia, Gilbert Hélène, Vignoles Florence, Créchet Françoise, Shimogiri Takeshi, Yasue Hiroshi, Leplat Jean-Jacques, Bouet Stephan, Gruand Joseph, Horak Vratislav, Milan Denis, Le Roy Pascale, Geffrotin Claudine

Abstract excerpt

Human cutaneous melanoma is a complex trait inherited in about 10% of cases. Although 2 high-risk genes, CDKN2A and CDK4, and 1 low risk gene, MC1R, have been identified, susceptibility genes remain to be discovered. Here, we attempted to determine new genomic regions linked to melanoma using the pig MeLiM strain, which develops hereditary cutaneous melanomas. We applied quantitative trait loci (QTL) mapping...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 1

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Source

Identifiers

PMID: 17066441
DOI: 10.1002/ijc.22289

Genes

CDK4

Provenance

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