Article
Genetic and functional evaluation of MITF as a candidate gene for cutaneous melanoma predisposition in pigs.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Oct 2011
Bourneuf Emmanuelle, Du Zhi-Qiang, Estellé Jordi, Gilbert Hélène, Créchet Françoise, Piton Guillaume, Milan Denis, Geffrotin Claudine, Lathrop Mark, Demenais Florence, Rogel-Gaillard Claire, Vincent-Naulleau Silvia
Abstract excerpt
Cutaneous melanoma arises from transformed melanocytes and is caused mainly by environmental effects such as ultraviolet radiation and to a lesser extent by predisposing genetic variants. Only a few susceptibility genes for cutaneous melanoma have been identified so far in human; therefore, animal models represent a valuable alternative for genetic studies of this disease. In a previous quantitative trait locus...
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