Article
Malignant features of minipig melanomas prior to spontaneous regression.
Scientific reports - 22 Apr 2024
Débare Héloïse, Blanc Fany, Piton Guillaume, Leplat Jean-Jacques, Vincent-Naulleau Silvia, Rivière Julie, Vilotte Marthe, Marthey Sylvain, Lecardonnel Jérôme, Coville Jean-Luc, Estellé Jordi, Rau Andrea, Bourneuf Emmanuelle, Egidy Giorgia
Abstract excerpt
In MeLiM minipigs, melanomas develop around birth, can metastasize, and have histopathologic characteristics similar to humans. Interestingly, MeLiM melanomas eventually regress. This favorable outcome raises the question of their malignancy, which we investigated. We clinically followed tens of tumors from onset to first signs of regression. Transcriptome analysis revealed an enrichment of all cancer hallmarks...
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