Article
Three functional mutation sites affect the immune response of pigs through altering the expression pattern and IgV domain of the CD4 protein.
BMC molecular and cell biology - 9 Dec 2020
Zhang Weiya, Ni Juan, Zhang Jie, Zhang Lu, Zhou Huanhuan, Zhao Changzhi, Zhu Mengjin, Wang Haiyan, Han Jianlin, Li Xinyun, Zhao Shuhong
Abstract excerpt
BACKGROUND: The CD4 protein is an important surface marker of T lymphocytes, which can mediate the antigen presentation process by interacting with MHC II and TCR molecules in human and mouse. RESULTS: In this study, two haplotypes (A and B) of the CD4 gene were found within Chinese indigenous and Western commercial pig breeds. These two haplotypes were defined by 22 fully linked SNPs in the CDS region of the CD4...
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