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Article

The chemical genomic portrait of yeast: uncovering a phenotype for all genes.

Science (New York, N.Y.) - 18 Apr 2008

Hillenmeyer Maureen E, Fung Eula, Wildenhain Jan, Pierce Sarah E, Hoon Shawn, Lee William, Proctor Michael, St Onge Robert P, Tyers Mike, Koller Daphne, Altman Russ B, Davis Ronald W, Nislow Corey, Giaever Guri

Abstract excerpt

Genetics aims to understand the relation between genotype and phenotype. However, because complete deletion of most yeast genes ( approximately 80%) has no obvious phenotypic consequence in rich medium, it is difficult to study their functions. To uncover phenotypes for this nonessential fraction of the genome, we performed 1144 chemical genomic assays on the yeast whole-genome heterozygous and homozygous...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18420932
DOI: 10.1126/science.1150021
PMCID: PMC2794835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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