Article
The chemical genomic portrait of yeast: uncovering a phenotype for all genes.
Science (New York, N.Y.) - 18 Apr 2008
Hillenmeyer Maureen E, Fung Eula, Wildenhain Jan, Pierce Sarah E, Hoon Shawn, Lee William, Proctor Michael, St Onge Robert P, Tyers Mike, Koller Daphne, Altman Russ B, Davis Ronald W, Nislow Corey, Giaever Guri
Abstract excerpt
Genetics aims to understand the relation between genotype and phenotype. However, because complete deletion of most yeast genes ( approximately 80%) has no obvious phenotypic consequence in rich medium, it is difficult to study their functions. To uncover phenotypes for this nonessential fraction...
Topics
- Culture Media
- Drug Resistance, Multiple, Fungal
- Gene Deletion
- Genes, Essential
- Genes, Fungal
- Genes, MDR
- Genome, Fungal
- Genomics
- Heterozygote
- Homozygote
- Metabolic Networks and Pathways
- Multigene Family
- Phenotype
- Saccharomyces cerevisiae