Article
Serum IFN-λ3 Levels Correlate with Serum Hepatitis C Virus RNA Levels in Symptomatic Patients with Acute Hepatitis C.
Digestive diseases (Basel, Switzerland) - 1 Jan 2017
Imoto Susumu, Kim Soo Ryang, Amano Keisuke, Iio Etsuko, Yoon Seitetsu, Hirohata Shigeya, Yano Yoshihiko, Ishikawa Toru, Katsushima Shinji, Komeda Toshiki, Fukunaga Toyokazu, Chung Hobyung, Kokuryu Hiroyuki, Horie Yutaka, Hatae Takashi, Fujinami Aya, Kim Soo Ki, Kudo Masatoshi, Tanaka Yasuhito
Abstract excerpt
BACKGROUND: Recent genome-wide association studies demonstrated that 2 single nucleotide polymorphisms (SNPs), upstream of the interferon-λ (IFNL) 3 gene, are associated with the spontaneous clearance of hepatitis C virus (HCV) in symptomatic patients with acute hepatitis C (AHC). Although these 2 SNPs, rs8099917 and rs12979860, have established their significant roles in the innate immunity response to...
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