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Article

IFNL3 genotype is associated with differential induction of IFNL3 in primary human hepatocytes.

Antiviral therapy - 1 Jan 2015

Kurbanov Fuat, Kim Yonghak, Latanich Rachel, Chaudhari Pooja, El-Diwany Ramy, Knabel Matt, Kandathil Abraham J, Cameron Andrew, Cox Andrea, Jang Yoon-Young, Thomas David L, Balagopal Ashwin

Abstract excerpt

BACKGROUND: Lambda interferons (IFNLs) have potent antiviral activity against HCV, and polymorphisms within the IFNL gene cluster near the IFNL3 gene strongly predict spontaneous- and treatment-related HCV infection outcomes. The mechanism(s) linking IFNL polymorphisms and HCV control is currently elusive. METHODS: IFNL induction was studied in primary human hepatocytes (PHH) from 18 human donors, peripheral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26109548
DOI: 10.3851/IMP2974
PMCID: PMC4821403

Genes

IFNL3
IFNL1
IFNL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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