Article
IL28B polymorphisms and clinical implications for hepatitis C virus infection in Uzbekistan.
PloS one - 1 Jan 2014
Khudayberganova Dinara, Sugiyama Masaya, Masaki Naohiko, Nishida Nao, Mukaide Motokazu, Sekler Dildora, Latipov Renat, Nataliya Kan, Dildora Suyarkulova, Sharapov Said, Usmanova Guzal, Raxmanov Mahmarajab, Musabaev Erkin, Mizokami Masashi
Abstract excerpt
AIMS: Genome-wide association studies highlighted single nucleotide polymorphisms (SNPs) within the IFNL3/IL28B locus predict the treatment outcome for patients with HCV. Furthermore, SNPs in newly discovered IFNL4 are shown to have population-specific correlation with spontaneous clearance of HCV. The aim of this study was to examine the prevalence and clinical significance of the outlined SNPs in a population...
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