Article
Association of serum IFN-λ3 with inflammatory and fibrosis markers in patients with chronic hepatitis C virus infection.
Journal of gastroenterology - 1 Aug 2015
Aoki Yoshihiko, Sugiyama Masaya, Murata Kazumoto, Yoshio Sachiyo, Kurosaki Masayuki, Hashimoto Satoru, Yatsuhashi Hiroshi, Nomura Hideyuki, Kang Jong-Hon, Takeda Tsutomu, Naito Shigeko, Kimura Tatsuji, Yamagiwa Yoko, Korenaga Masaaki, Imamura Masatoshi, Masaki Naohiko, Izumi Namiki, Kage Masayoshi, Mizokami Masashi, Kanto Tatsuya
Abstract excerpt
BACKGROUND: Hepatitis C virus (HCV) is one of the major causes of liver cancer. The single nucleotide polymorphisms within the IFNL3 gene, which encodes interferon (IFN)-λ(3), are strongly associated with the response to pegylated IFN-α (PEG-IFN-α) plus ribavirin (RBV) therapy in chronic hepatitis C (C-CH) patients. However, the roles of IFN-λ(3) in chronic HCV infection are still elusive. In this study, we aimed...
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