Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IHF redistributes bound initiator protein, DnaA, on supercoiled oriC of Escherichia coli.

Molecular microbiology - 1 Feb 2000

Grimwade J E, Ryan V T, Leonard A C

Abstract excerpt

In Escherichia coli, initiation of chromosome replication requires that DnaA binds to R boxes (9-mer repeats) in oriC, the unique chromosomal replication origin. At the time of initiation, integration host factor (IHF) also binds to a specific site in oriC. IHF stimulates open complex formation by DnaA on supercoiled oriC in cell-free replication systems, but it is unclear whether this stimulation involves...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Binding Sites
Share to DNA Footprinting

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Superhelical

Share to Escherichia coli

Share to Integration Host Factors

Share to Nucleic Acid Conformation

Share to Replication Origin

Source

Identifiers

PMID: 10692160
DOI: 10.1046/j.1365-2958.2000.01755.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IHF redistributes bound initiator protein, DnaA, on supercoiled oriC of Escherichia coli.PMID 10692160Read ↗

Regulatory dynamics in the ternary DnaA complex for initiation of chromosomal replication in Escherichia coli.Semantic proximity Read ↗

The DnaA box R4 in the minimal oriC is dispensable for initiation of Escherichia coli chromosome replication.Semantic proximity Read ↗

Replication of the Escherichia coli chromosome in RNase HI-deficient cells: multiple initiation regions and fork dynamics.Semantic proximity Read ↗

A comprehensive set of DnaA-box mutations in the replication origin, oriC, of Escherichia coli.Semantic proximity Read ↗

Hyperinitiation of DNA replication in Escherichia coli leads to replication fork collapse and inviability.Semantic proximity Read ↗

The sequence requirements for a functional Escherichia coli replication origin are different for the chromosome and a minichromosome.Semantic proximity Read ↗

Transcriptional control for initiation of chromosomal replication in Escherichia coli: fluctuation of the level of origin transcription ensures timely initiation.Semantic proximity Read ↗

The requirement of IHF protein for extrachromosomal replication of the Escherichia coli oriC in a mutant deficient in DNA polymerase I activity.Semantic proximity Read ↗

Negative control of replication initiation by a novel chromosomal locus exhibiting exceptional affinity for Escherichia coli DnaA protein.Semantic proximity Read ↗

Controlled initiation of chromosomal replication in Escherichia coli requires functional Hda protein.Semantic proximity Read ↗

Eclipse-synchrony relationship in Escherichia coli strains with mutations affecting sequestration, initiation of replication and superhelicity of the bacterial chromosome.Semantic proximity Read ↗

Bacterial origin recognition complexes direct assembly of higher-order DnaA oligomeric structures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.