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Article

Topological characterization of the DnaA-oriC complex using single-molecule nanomanipuation.

Nucleic acids research - 1 Aug 2012

Zorman Sylvain, Seitz H, Sclavi B, Strick T R

Abstract excerpt

In most bacteria, the timing and synchrony of initiation of chromosomal replication are determined by the binding of the AAA(+) protein DnaA to a set of high- and low-affinity sites found within the origin of chromosomal replication (oriC). Despite the large amount of information on the role and regulation of DnaA, the actual structure of the DnaA-oriC complex and the mechanism by which it primes the origin for...

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Identifiers

PMID: 22581769
DOI: 10.1093/nar/gks371
PMCID: PMC3424547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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