Article
Phenotyping of autoreactive B cells with labeled nucleosomes in 56R transgenic mice.
Scientific reports - 16 Oct 2017
Gies Vincent, Bouis Delphine, Martin Mickaël, Pasquali Jean-L, Martin Thierry, Korganow Anne-S, Soulas-Sprauel Pauline
Abstract excerpt
The phenotypic characterization of self-reactive B cells producing autoantibodies is one of the challenges to get further insight in the physiopathology of autoimmune diseases. We took advantage of our previously developed flow cytometry method, using labeled nucleosomes, prominent autoantigens in systemic lupus erythematosus, to analyze the phenotype of self-reactive B cells in the anti-DNA B6.56R mouse model....
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