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Article

Visualization of the genesis and fate of isotype-switched B cells during a primary immune response.

The Journal of experimental medicine - 16 Jun 2003

Pape Kathryn A, Kouskoff Valerie, Nemazee David, Tang H Lucy, Cyster Jason G, Tze Lina E, Hippen Keli L, Behrens Timothy W, Jenkins Marc K

Abstract excerpt

The life history of isotype-switched B cells is unclear, in part, because of an inability to detect rare antigen-specific B cells at early times during the immune response. To address this issue, a small population of B cells carrying targeted antibody transgenes capable of class switching was monitored in immunized mice. After contacting helper T cells, the first switched B cells appeared in follicles rather...

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Identifiers

PMID: 12796466
DOI: 10.1084/jem.20012065
PMCID: PMC2193962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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