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Article

Consequences of receptor editing at the lambda locus: multireactivity and light chain secretion.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jul 2006

Doyle Colleen M, Han Jiong, Weigert Martin G, Prak Eline T Luning

Abstract excerpt

To investigate the manner in which B cells with lambda light (L) chains undergo receptor editing, we have studied hybridoma panels from 56R/kappa-deleted (kdel) mice. 56R/kdel mice only produce four L chains (lambda1, lambda2, lambda3, and lambdaX). They also have a simplified heavy (H) chain repertoire: All B cells start out with a 56R anti-DNA H chain. A few frankly autoreactive 56R lambda1 cells appear to...

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Identifiers

PMID: 16847259
DOI: 10.1073/pnas.0604053103
PMCID: PMC1544076

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Source receipt: pubmed, retrieved 7 Sept 2026.

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