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Article

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1 May 1993

Abstract excerpt

Only a fraction (12%) of 268 "autoreactive" T cell clones derived from lupus-prone mice can selectively induce the production of pathogenic anti-DNA autoantibodies in vitro and accelerate the development of lupus nephritis when transferred in vivo. The CDR3 loops of T cell receptor beta chains expressed by these pathogenic T helper (Th) clones contain a recurrent motif of anionic residues suggesting that they are...

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Identifiers

PMID: 8478612
DOI: 10.1084/jem.177.5.1367

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