Article
Distinct phenotypes of plasma cells in spleen and bone marrow of autoimmune NOD.B10.H2b mice.
Autoimmunity - 1 Aug 2011
Szyszko Ewa A, Skarstein Kathrine, Jonsson Roland, Brokstad Karl A
Abstract excerpt
Long-lived plasma cells (PCs) residing in the bone marrow (BM) are important producers of protective antibodies. However, when reacting against self-antigens, these PCs produce autoantibodies that contribute to progression of autoimmune diseases such as Sjögren's syndrome (SS). By using a murine model of primary SS, the NOD.B10.H2b mice, we characterized phenotype and generation of PCs at different stages of the...
Topics
- Animals
- Autoantibodies
- Autoimmune Diseases
- Autoimmunity
- Bone Marrow
- Cell Movement
- Cell Proliferation
- Cell Survival
- Female
- Gene Expression Regulation
- Immunoglobulin Isotypes