Article
Allelic and isotypic light chain inclusion in peripheral B cells from anti-DNA antibody transgenic C57BL/6 and BALB/c mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2008
Witsch Esther J, Bettelheim Eldad
Abstract excerpt
Most mature B lymphocytes express one BCR L chain, kappa or lambda, but recent work has shown that there are exceptions in that some B lymphocytes express both kappa and lambda and some even bear two different kappa L chains. Using the anti-DNA H chain-transgenic mouse, 56R, we find that B cells with pre-existing autoreactivity are especially subject to L chain inclusion. Specifically, we show that isotypic and...
Topics
- Alleles
- Animals
- Antibodies, Antinuclear
- B-Lymphocyte Subsets
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Immunoglobulin Constant Regions
- Immunoglobulin Isotypes
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Immunoglobulin lambda-Chains
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL