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Article

Allelic and isotypic light chain inclusion in peripheral B cells from anti-DNA antibody transgenic C57BL/6 and BALB/c mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2008

Witsch Esther J, Bettelheim Eldad

Abstract excerpt

Most mature B lymphocytes express one BCR L chain, kappa or lambda, but recent work has shown that there are exceptions in that some B lymphocytes express both kappa and lambda and some even bear two different kappa L chains. Using the anti-DNA H chain-transgenic mouse, 56R, we find that B cells with pre-existing autoreactivity are especially subject to L chain inclusion. Specifically, we show that isotypic and...

Read the complete abstract on PubMed

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Share to Antibodies, Antinuclear
Share to B-Lymphocyte Subsets

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte, Light Chain

Share to Immunoglobulin Constant Regions

Share to Immunoglobulin Isotypes

Share to Immunoglobulin kappa-Chains

Share to Immunoglobulin lambda-Chains

Share to Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 18322176
DOI: 10.4049/jimmunol.180.6.3708

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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