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Article

Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2006

Lartigue Aurelia, Courville Philippe, Auquit Isabelle, François Arnaud, Arnoult Christophe, Tron François, Gilbert Daniele, Musette Philippe

Abstract excerpt

Systemic lupus erythematosus is characterized by the production of autoantibodies directed against nuclear Ags, including nucleosome and DNA. TLR9 is thought to play a role in the production of these autoantibodies through the capacity of nuclear immunogenic particles to interact both with BCR and TLR9. To determine the role of TLR9 in SLE, C57BL/6-lpr/lpr-TLR9(-/-) and TLR9(+/+) mice were analyzed. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16818796
DOI: 10.4049/jimmunol.177.2.1349

Genes

TLR9
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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