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Zeb1 induces immune checkpoints to form an immunosuppressive envelope around invading cancer cells

21 May 2021

Abstract excerpt

The PDL1-PD1 immune checkpoint inhibits T cell activation, and its blockade is effective in a subset of patients. Studies are investigating how checkpoints are hijacked by cancer cells and why most patients remain resistant to immunotherapy. Epithelial mesenchymal transition (EMT), which drives tumor cell invasion via the Zeb1 transcription factor, is linked to immunotherapy resistance. In addition, M2-polarized...

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PMID: 34020945
DOI: 10.1126/sciadv.abd7455

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