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Article

Functional Hierarchy and Cooperation of EMT Master Transcription Factors in Breast Cancer Metastasis

26 Jan 2021

Abstract excerpt

Abstract Several master transcription factors (TF) can activate the epithelial-to-mesenchymal transition (EMT). However, their individual and combinatorial contributions to EMT in breast cancer are not defined. We show that overexpression of EMT-TFs individually in epithelial cells upregulated endogenous SNAI2, ZEB1/2, TCF4, and TWIST1/2 as a result of positive feedback mediated in part by suppression of their...

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PMID: 33500360
DOI: 10.1158/1541-7786.mcr-20-0532

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