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Article

A stroma-corrected ZEB1 transcriptional signature is inversely associated with antitumor immune activity in breast cancer

28 Nov 2019

Abstract excerpt

The epithelial-to-mesenchymal transition (EMT) is an essential developmental process which can be hijacked by cancer cells, leading to enhanced metastasis and chemoresistance in experimental models. Recent studies have linked gene expression of EMT-associated gene signatures to increased inflammatory immune response in multiple cancer types. However, these studies did not account for the potential confounding...

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PMID: 31780722
DOI: 10.1038/s41598-019-54282-z

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