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Article

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression

1 Aug 2012

Abstract excerpt

Metastatic cancer is extremely difficult to treat, and the presence of metastases greatly reduces a cancer patient's likelihood of long-term survival. The ZEB1 transcriptional repressor promotes metastasis through downregulation of microRNAs (miRs) that are strong inducers of epithelial differentiation and inhibitors of stem cell factors. Given that each miR can target multiple genes with diverse functions, we...

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PMID: 22850877
DOI: 10.1172/jci63608

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