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Article

Dualistic role of ZEB1 and ZEB2 in tumor progression

20 Mar 2025

Abstract excerpt

It is generally accepted that ZEB1 and ZEB2 act as master regulators of the epithelial-mesenchymal transition, which arguably is the key mechanism of metastasis. Accordingly, they are deemed as negative predictors of the survival of cancer patients by promoting the emergence of secondary foci of the disease. Paradoxically, in some types of cancer types the opposite effect is observed, i.e. ZEB1 and ZEB2 are...

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PMID: 40114235
DOI: 10.1186/s13062-025-00604-3

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