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Article

Associations of interactions between NLRP3 SNPs and HLA mismatch with acute and extensive chronic graft-versus-host diseases.

Scientific reports - 12 Oct 2017

Takahashi Hidekazu, Okayama Naoko, Yamaguchi Natsu, Miyahara Yuta, Morishima Yasuo, Suehiro Yutaka, Yamasaki Takahiro, Tamada Koji, Takahashi Satoshi, Tojo Arinobu, Asano Shigetaka, Tanabe Tsuyoshi

Abstract excerpt

HLA matching is a well-known genetic requirement for successful bone marrow transplantation (BMT). However, the importance of non-HLA single-nucleotide polymorphisms (SNPs) remains poorly understood. The NLR family pyrin domain-containing 3 (NLRP3) inflammasome, a key regulator of innate immunity, is associated with multiple diseases. We retrospectively genotyped SNPs of NLRP1-3 and caspase recruitment domain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29026154
DOI: 10.1038/s41598-017-13506-w
PMCID: PMC5638959

Genes

NLRP3
CARD8
NLRP1

Provenance

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