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Article

Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: analysis of BMT CTN-0201 and -0901 samples.

British journal of haematology - 1 Sept 2018

Rashidi Armin, Shanley Ryan, Yohe Sophia L, Thyagarajan Bharat, Curtsinger Julie, Anasetti Claudio, Waller Edmund K, Scott Bart L, Blazar Bruce R, Weisdorf Daniel J

Abstract excerpt

Host genetics shape the gut microbiota, and gut dysbiosis increases the risk of acute graft-versus-host disease (aGVHD). Paneth cells and microbiota have interactions that contribute to immune regulation. α-defensin-5 (HD5) and regenerating islet-derived protein 3 alpha (Reg3A) are the most abundant Paneth cell antimicrobial peptides (AMPs). We hypothesized that single nucleotide polymorphisms (SNPs) in the genes...

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Identifiers

PMID: 30004111
DOI: 10.1111/bjh.15492
PMCID: PMC6128755

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DEFA5

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