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Article

Matching for the MICA-129 polymorphism is beneficial in unrelated hematopoietic stem cell transplantation

3 Nov 2016

Abstract excerpt

Major histocompatibility complex class I polypeptide-related sequence A (MICA) is a highly polymorphic ligand of the activating NKG2D receptor on natural killer (NK) cells, γδ-T cells, and NKT cells. MICA incompatibilities have been associated with an increased graft-versus-host disease (GVHD) incidence, and the MICA-129 (met/val) dimorphism has been shown to influence NKG2D signaling in unrelated hematopoietic...

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PMID: 27811019
DOI: 10.1182/blood-2016-05-716357

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