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Article

MHC-resident variation affects risks after unrelated donor hematopoietic cell transplantation.

Science translational medicine - 25 Jul 2012

Petersdorf Effie W, Malkki Mari, Gooley Theodore A, Spellman Stephen R, Haagenson Michael D, Horowitz Mary M, Wang Tao

Abstract excerpt

Blood malignancies can be cured with hematopoietic cell transplantation from human leukocyte antigen (HLA)-matched unrelated donors; however, acute graft-versus-host disease (GVHD) affects up to 80% of patients and contributes to increased mortality. To test the hypothesis that undetected patient-donor differences for non-HLA genetic variation within the major histocompatibility complex (MHC) could confer risks...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22837536
DOI: 10.1126/scitranslmed.3003974
PMCID: PMC3633562

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