Genome-wide meta-analysis associates donor-recipient non-HLA genetic mismatch with acute cellular rejection post-liver transplantation.

doi:10.1097/HC9.0000000000000601

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Genome-wide meta-analysis associates donor-recipient non-HLA genetic mismatch with acute cellular rejection post-liver transplantation.

Hepatology communications - 1 Jan 2025

Nieuwenhuis Lianne M, Li Yanni, Loza Bao-Li, Lambeck Annechien J A, Hu Shixian, Gacesa Ranko, Voskuil Michiel D, Hepkema Bouke G, Jansen Bernadien H, Blokzijl Hans, Verkade Henk-Jan, van den Heuvel Marius C, Asrani Sumeet, Testa Giuliano, Klintmalm Goran, Trotter James, Olthoff Kim M, Shaked Abraham, Keating Brendan J, Weersma Rinse K, Festen Eleonora A M, de Meijer Vincent E

Abstract excerpt

BACKGROUND: Acute cellular rejection (ACR) remains a common complication causing significant morbidity post-liver transplantation. Non-human leukocyte antigen (non-HLA) mismatches were associated with an increased risk of ACR in kidney transplantation. Therefore, we hypothesized that donor-recipient non-HLA genetic mismatch is associated with increased ACR incidence post-liver transplantation. METHODS: We...

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PMID: 39670865
DOI: 10.1097/HC9.0000000000000601
PMCID: PMC11637756

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