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Article

3p21.3 tumor suppressor cluster: prospects for translational applications

1 Feb 2005

Abstract excerpt

Chromosomal abnormalities at the 3p21.3 region, including homozygous deletions and loss of heterozygosity and expressional deficiencies in 3p21.3 genes including transcriptional silences by promoter hypermethylation, altered mRNA splicing and aberrant transcripts, and lost or defect protein translation and post-translational modifications, are frequently found in most human cancers. Inactivation of 3p21.3 genes...

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PMID: 16555978
DOI: 10.1517/14796694.1.1.79

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