Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster.

PloS one - 3 Mar 2010

Shirinian Margret, Popovic Milica, Grabbe Caroline, Varshney Gaurav, Hugosson Fredrik, Bos Hans, Rehmann Holger, Palmer Ruth H

Abstract excerpt

C3G is a guanine nucleotide exchange factor (GEF) and modulator of small G-protein activity, which primarily acts on members of the Rap GTPase subfamily. Via promotion of the active GTP bound conformation of target GTPases, C3G has been implicated in the regulation of multiple cellular and develo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila melanogaster
Share to Drosophila Proteins
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrins

Share to Microscopy, Confocal

Share to Muscles

Share to rap1 GTP-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20209136
DOI: 10.1371/journal.pone.0009403
PMCID: PMC2831063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20209136-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster.PMID 20209136Read ↗

Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factorSemantic proximity Read ↗

The guanine nucleotide exchange factor C3G is necessary for the formation of focal adhesions and vascular maturation.Semantic proximity Read ↗

Complex formation and reciprocal regulation between GSK3β and C3G.Semantic proximity Read ↗

Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis.Semantic proximity Read ↗

Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas.Semantic proximity Read ↗

Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.Semantic proximity Read ↗

Fine-Tuning of the Actin Cytoskeleton and Cell Adhesion During Drosophila Development by the Unconventional Guanine Nucleotide Exchange Factors Myoblast City and Sponge.Semantic proximity Read ↗

Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).Semantic proximity Read ↗

Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanismsSemantic proximity Read ↗

The Ccm3-GckIII signaling axis regulates Rab11-dependent recycling to the apical compartmentSemantic proximity Read ↗

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.Semantic proximity Read ↗

Kindlins in FERM adhesionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.