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Article

Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2009

Kampa Kerstin M, Acoba Jared D, Chen Dexi, Gay Joel, Lee Hunjoo, Beemer Kelly, Padiernos Emerson, Boonmark Nataya, Zhu Zhiyi, Fan Alice C, Bailey Alexis S, Fleming William H, Corless Christopher, Felsher Dean W, Naumovski Louie, Lopez Charles D

Abstract excerpt

The expression of ASPP2 (53BP2L), a proapoptotic member of a family of p53-binding proteins, is frequently suppressed in many human cancers. Accumulating evidence suggests that ASPP2 inhibits tumor growth; however, the mechanisms by which ASPP2 suppresses tumor formation remain to be clarified. T...

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Identifiers

PMID: 19251665
DOI: 10.1073/pnas.0809080106
PMCID: PMC2657427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19251665-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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