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Article

brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury.

Scientific reports - 18 Jan 2022

Kouprianov Vassili A, Selmek Aubrie A, Ferguson Jordan L, Mo Xiaokui, Shive Heather R

Abstract excerpt

Cancer cells frequently co-opt molecular programs that are normally activated in specific contexts, such as embryonic development and the response to injury. Determining the impact of cancer-associated mutations on cellular phenotypes within these discrete contexts can provide new insight into how such mutations lead to dysregulated cell behaviors and subsequent cancer onset. Here we assess the impact of...

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Identifiers

PMID: 35042909
DOI: 10.1038/s41598-022-04878-9
PMCID: PMC8766490

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