Article
Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1.
Molecular and cellular biology - 1 Nov 2004
Kim Sang Soo, Cao Liu, Li Cuiling, Xu Xiaoling, Huber L Julie, Chodosh Lewis A, Deng Chu-Xia
Abstract excerpt
The tumor suppressor BRCA1 contains multiple functional domains that interact with many proteins. After DNA damage, BRCA1 is phosphorylated by CHK2 at serine 988, followed by a change in its intracellular location. To study the functions of CHK2-dependent phosphorylation of BRCA1, we generated a mouse model carrying the mutation S971A (S971 in mouse Brca1 corresponds to S988 in human BRCA1) by gene targeting....
Topics
- Aging
- Animals
- BRCA1 Protein
- Carcinogens
- Cell Cycle
- Cell Transformation, Neoplastic
- Checkpoint Kinase 2
- DNA Damage
- Female
- Gamma Rays
- Hyperplasia
- Mammary Glands, Animal
- Methylnitronitrosoguanidine