Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells.

PloS one - 1 Jan 2017

Somanath Priyanka, Herndon Klein Rachel, Knoepfler Paul S

Abstract excerpt

The transcriptional functions of the class I histone deacetylases (HDACs) HDAC1 and HDAC2 are mainly viewed as both repressive and redundant based on murine knockout studies, but they may have additional independent roles and their physiological functions in human cells are not as clearly defined. To address the individual epigenomic functions of HDAC2, here we utilized CRISPR-Cas9 to disrupt HDAC2 in human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Chromatin Immunoprecipitation
Share to Clustered Regularly Interspaced Short Palindromic Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to HEK293 Cells

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Sequence Analysis, RNA

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 28982113
DOI: 10.1371/journal.pone.0185627
PMCID: PMC5628847

Genes

HDAC2
HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells.PMID 28982113Read ↗

Programmable CRISPRtune dissects the transcriptional repressive activity of MeCP2Semantic proximity Read ↗

A lentivirus-free inducible CRISPR-Cas9 system for efficient targeting of human genes.Semantic proximity Read ↗

Inhibition of Histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editingSemantic proximity Read ↗

Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.Semantic proximity Read ↗

De-novo DNA Methylation of Bivalent Promoters Induces Gene Activation through PRC2 DisplacementSemantic proximity Read ↗

The HDAC2-MTA3 interaction induces nonsmall cell lung cancer cell migration and invasion by targeting c-Myc and cyclin D1.Semantic proximity Read ↗

Bidirectional epigenetic editing reveals hierarchies in gene regulationSemantic proximity Read ↗

Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9-mediated genome engineering in HAP1 cells mimicking cancer profiles.Semantic proximity Read ↗

Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factorsSemantic proximity Read ↗

Transforming pathways unleashed by a HDAC2 mutation in human cancer.Semantic proximity Read ↗

Characterization of a novel HDAC2 pathogenetic variant: a missing puzzle piece for chromatinopathies.Semantic proximity Read ↗

KDM6A knockout in human iPSCs alters the genome-wide histone methylation profile at active and poised enhancers, activating expression of ectoderm gene expression pathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.