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Article

Transforming pathways unleashed by a HDAC2 mutation in human cancer.

Oncogene - 26 Jun 2008

Ropero S, Ballestar E, Alaminos M, Arango D, Schwartz S, Esteller M

Abstract excerpt

Although disruption of histone modification patterns is a common hallmark of human cancer, our knowledge of the mechanistic role of histone-modifying enzymes in its generation is very limited. We have recently identified an inactivating mutation in the histone deacetylase-2 (HDAC2) in sporadic carcinomas with microsatellite instability and in tumors arising in individuals with hereditary nonpolyposis colorectal...

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Topics

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Share to Chromatin
Share to Cluster Analysis
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Histone Deacetylases

Share to Histones

Share to Neovascularization, Pathologic

Share to Repressor Proteins

Source

Identifiers

PMID: 18264134
DOI: 10.1038/onc.2008.31

Genes

HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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