Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The HDAC2-MTA3 interaction induces nonsmall cell lung cancer cell migration and invasion by targeting c-Myc and cyclin D1.

Molecular carcinogenesis - 1 Nov 2023

Wang Bin, Shen Xiao-Yong, Pan Lin-Yue, Li Zheng, Chen Chun-Ji, Yao Yuan-Shan, Tang Dong-Fang, Gao Wen

Abstract excerpt

Genome-wide association studies have identified numerous single-nucleotide polymorphisms (SNPs) associated with lung cancer; however, the functions of histone deacetylase 2 (HDAC2) rs13213007 and HDAC2 in nonsmall cell lung cancer (NSCLC) remain unclear. Here we identified HDAC2 rs13213007 as a risk SNP and showed that HDAC2 was upregulated in both peripheral blood mononuclear cells (PBMCs) and NSCLC tissues with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung
Share to Cell Movement
Share to Cell Proliferation
Share to Cyclin D1
Share to Gene Expression Regulation, Neoplastic
Share to Histone Deacetylases
Share to Neoplasm Invasiveness
Share to Proto-Oncogene Proteins c-myc

Source

Identifiers

PMID: 37401867
DOI: 10.1002/mc.23604

Genes

HDAC2
MTA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The HDAC2-MTA3 interaction induces nonsmall cell lung cancer cell migration and invasion by targeting c-Myc and cyclin D1.PMID 37401867Read ↗

Exome sequencing identifies frequent mutation of MLL2 in non-small cell lung carcinoma from Chinese patients.Semantic proximity Read ↗

Pan-Cancer Analysis of Histone Methyltransferase KMT2D with Potential Implications for Prognosis and Immunotherapy in Human CancerSemantic proximity Read ↗

DNMT3A triggers tumorigenesis of non-small cell lung cancer through regulation of SLIT2 methylation and SLIT2-mediated macrophage M1/M2 polarizationSemantic proximity Read ↗

Epigenetic therapy in non-small-cell lung cancer: targeting DNA methyltransferases and histone deacetylasesSemantic proximity Read ↗

SNP rs10248565 in HDAC9 as a novel genomic aberration biomarker of lung adenocarcinoma in non-smoking women.Semantic proximity Read ↗

CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells.Semantic proximity Read ↗

Emerging role of SIRT2 in non-small cell lung cancer (Review)Semantic proximity Read ↗

Recruitment of KMT2C/MLL3 to DNA Damage Sites Mediates DNA Damage Responses and Regulates PARP Inhibitor Sensitivity in Cancer.Semantic proximity Read ↗

Loss of CDKN2A at chromosome 9 has a poor clinical prognosis and promotes lung cancer progressionSemantic proximity Read ↗

c-Myc suppresses microRNA-29b to promote tumor aggressiveness and poor outcomes in non-small cell lung cancer by targeting FHITSemantic proximity Read ↗

Metformin Reduces Histone H3K4me3 at the Promoter Regions of Positive Cell Cycle Regulatory Genes in Lung Cancer CellsSemantic proximity Read ↗

SIRT2 suppresses non-small cell lung cancer growth by targeting JMJD2ASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.