Article
Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.
JAMA neurology - 1 Dec 2017
Woerman Amanda L, Patel Smita, Kazmi Sabeen A, Oehler Abby, Freyman Yevgeniy, Espiritu Lloyd, Cotter Robert, Castaneda Julian A, Olson Steven H, Prusiner Stanley B
Abstract excerpt
Importance: Accumulation of the protein tau is a defining characteristic of several neurodegenerative diseases. Thorough assessment of transgenic (Tg) mouse lines that replicate this process is critical for establishing the models used for testing anti-tau therapeutics in vivo. Objective: To define a consistent mouse model of disease for use in future compound efficacy studies. Design, Setting, and Participants:...
Topics
- Animals
- Brain
- Disease Models, Animal
- Female
- Hemizygote
- Homozygote
- Humans
- Kinetics
- Male
- Mice
- Mice, Transgenic
- Mutation