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Article

Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.

JAMA neurology - 1 Dec 2017

Woerman Amanda L, Patel Smita, Kazmi Sabeen A, Oehler Abby, Freyman Yevgeniy, Espiritu Lloyd, Cotter Robert, Castaneda Julian A, Olson Steven H, Prusiner Stanley B

Abstract excerpt

Importance: Accumulation of the protein tau is a defining characteristic of several neurodegenerative diseases. Thorough assessment of transgenic (Tg) mouse lines that replicate this process is critical for establishing the models used for testing anti-tau therapeutics in vivo. Objective: To define a consistent mouse model of disease for use in future compound efficacy studies. Design, Setting, and Participants:...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29059326
DOI: 10.1001/jamaneurol.2017.2822
PMCID: PMC5822201

Genes

MAPT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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