Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct αβ T cell receptors.

The Journal of biological chemistry - 22 Dec 2017

Sullivan Lucy C, Walpole Nicholas G, Farenc Carine, Pietra Gabriella, Sum Matthew J W, Clements Craig S, Lee Eleanor J, Beddoe Travis, Falco Michela, Mingari Maria Cristina, Moretta Lorenzo, Gras Stephanie, Rossjohn Jamie, Brooks Andrew G

Abstract excerpt

αβ T cell receptors (TCRs) interact with peptides bound to the polymorphic major histocompatibility complex class Ia (MHC-Ia) and class II (MHC-II) molecules as well as the essentially monomorphic MHC class Ib (MHC-Ib) molecules. Although there is a large amount of information on how TCRs engage with MHC-Ia and MHC-II, our understanding of TCR/MHC-Ib interactions is very limited. Infection with cytomegalovirus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Energy Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitope Mapping

Share to Epitopes, T-Lymphocyte

Share to HLA-E Antigens

Share to Molecular Docking Simulation

Share to Protein Interaction Domains and Motifs

Share to Receptors, Antigen, T-Cell, alpha-beta

Source

Open in PubMed Open full text

Identifiers

PMID: 28972140
DOI: 10.1074/jbc.M117.807719
PMCID: PMC5743087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct αβ T cell receptors.PMID 28972140Read ↗

Structural Basis for Unusual TCR CDR3β Usage Against an Immunodominant HIV-1 Gag Protein Peptide Restricted to an HLA-B*81:01 Molecule.Semantic proximity Read ↗

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometrySemantic proximity Read ↗

Conserved Biophysical Compatibility Among the Highly Variable Germline-Encoded Regions Shapes TCR-MHC InteractionsSemantic proximity Read ↗

Human T cells recognize HLA-DP–bound peptides in two orientationsSemantic proximity Read ↗

Allelic polymorphism in the T cell receptor and its impact on immune responses.Semantic proximity Read ↗

A molecular basis for the interplay between T cells, viral mutants, and human leukocyte antigen micropolymorphism.Semantic proximity Read ↗

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.Semantic proximity Read ↗

Unconventional Peptide Presentation by Major Histocompatibility Complex (MHC) Class I Allele HLA-A*02:01: BREAKING CONFINEMENT.Semantic proximity Read ↗

The basis for limited specificity and MHC restriction in a T cell receptor interface.Semantic proximity Read ↗

Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope.Semantic proximity Read ↗

CD8 Binding of MHC-Peptide Complexes in cis or trans Regulates CD8+ T-cell Responses.Semantic proximity Read ↗

A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.