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Article

Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope.

The Journal of biological chemistry - 10 Nov 2017

Yang Xinbo, Chen Guobing, Weng Nan-Ping, Mariuzza Roy A

Abstract excerpt

Influenza A virus (IAV) causes an acute infection in humans that is normally eliminated by CD8+ cytotoxic T lymphocytes. Individuals expressing the MHC class I molecule HLA-A2 produce cytotoxic T lymphocytes bearing T-cell receptors (TCRs) that recognize the immunodominant IAV epitope GILGFVFTL (GIL). Most GIL-specific TCRs utilize α/β chain pairs encoded by the TRAV27/TRBV19 gene combination to recognize this...

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Identifiers

PMID: 28931605
DOI: 10.1074/jbc.M117.810382
PMCID: PMC5683187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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