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Article

Structural Basis for Unusual TCR CDR3β Usage Against an Immunodominant HIV-1 Gag Protein Peptide Restricted to an HLA-B*81:01 Molecule.

Frontiers in immunology - 1 Jan 2022

Liu Yang, Lei Jun, San Dan, Yang Yi, Paek Chonil, Xia Zixiong, Chen Yongshun, Yin Lei

Abstract excerpt

In HIV infection, some closely associated human leukocyte antigen (HLA) alleles are correlated with distinct clinical outcomes although presenting the same HIV epitopes. The mechanism that underpins this observation is still unknown, but may be due to the essential features of HLA alleles or T cell receptors (TCR). In this study, we investigate how T18A TCR, which is beneficial for a long-term control of HIV in...

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Share to CD8-Positive T-Lymphocytes
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-B Antigens

Share to Immunodominant Epitopes

Share to Mutation

Share to Receptors, Antigen, T-Cell

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Identifiers

PMID: 35173732
DOI: 10.3389/fimmu.2022.822210
PMCID: PMC8841528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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